• Create a folder in which you will include a set folder (see below) including all the supplementary data.

• For each Figure, each Scheme and each Table of the article (and the supplementary information), include in a folder the file(s) used for their preparation.

Examples:

/Figure_1/main_reaction.cdx /Table_1/irradiation_conditions.xls

• For each compound for which you have spectra (NMR, IR, etc.), create a folder named according to the compound number in the paper and include:
  • 1) a structure file (typically a .cdx file of the structure of the compound).
  • 2) all the files of the different spectra you have (crude NMR in the spectrometer’s format, .mnova, jcamp, etc. files of all analytical technique you used - whether they are reported in the paper/supp. Information or not…

Examples:

Compound_1/starting_product.cdx

Compound_2/final_product.cdx Compound_2/NMR/St332_1/10/... (1D 1H spectrum) Compound_2/NMR/St332_1/11/... (1D 13C spectrum) Compound_2/NMR/St332_1/12/... (2D HSQC)  Compound_2/IR/st322.jcamp  Compound_2/EA/exact_mass.txt

• Compress the main folder in the form of a .zip file.
• Upload the zip file when submitting your article.

If the file is too large for the upload or if are worried that the Publisher will not make you supplementary data available for free to all reader, you can use a (free) service such as Zenodo or Figshare, etc. You can impose an embargo to the record. When the article is accepted, you simply click to make the data public. In the mean time and the service can generate a special hashed link that you paste in the article so that only reviewers can access the data. These service also generates a (permanent) doi which can be included in the body of the text so that readers can access them directly. This requires no action on the side of the editor of the journal.

PS. An option is to rename the folder numbers (10, 11, 12 in the file structure above) into 1D_1H, 1D_13C, HSQC, to facilitate the reviewer’s work.